Important acids include tetrahydrocannabinolic acid – the precursor of delta 9-THC (often simply called THC) and delta‑8‑THC – and cannabidiolic acid – the precursor of CBD. In raw plant material most of the cannabinoids are present as carboxylic acids which can undergo decarboxylation induced by heat in production processes, smoking or even in gas chromatographic analyses (see Figure 1). Cannabinoid contents of the seeds primarily result from contamination with other parts of the plant. As such, the enormous market potential for CBD has grown further, driving an increased need for specific and robust analytical methods for the quantification of cannabinoids.Īlmost all parts of the hemp plant, with the exception of the seeds, contain cannabinoids (>100 substances known so far) which are produced by glandular hairs. This decision cleared the path for future applications in Novel Food and overturned a ban in France on the marketing of hemp-derived CBD products, which the court said contradicted EU law on the free movement of goods. Figure 1: Excerpt from cannabinoid biosynthesis
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